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Browse > Pharmacology & Drug Discovery > Respiratory Pharmacology
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Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
 Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice.
Harmon GS, Dumlao DS, …, Dong H, Glass CK
Nat Med 2010 Mar 16(3):313-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William H Colledge / Hugo De Jonge
First evaluation 15 Mar 2010 | Latest evaluation 18 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations.
Perez-Zoghbi JF, Bai Y, Sanderson MJ
J Gen Physiol 2010 Mar 135(3):247-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeremy Ward
Evaluated 8 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors.
Naura AS, Hans CP, …, Kim JG, Boulares AH
Lab Invest 2009 Nov 89(11):1243-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sara Rosenkranz and Craig Harms
Evaluated 18 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Lung Opening and Closing During Ventilation of Acute Respiratory Distress Syndrome.
Caironi P, Cressoni M, …, Caspani L, Gattinoni L
Am J Respir Crit Care Med 2009 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Jason HT Bates
Evaluated 17 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 Notch3 signaling promotes the development of pulmonary arterial hypertension.
Li X, Zhang X, …, Jamieson SW, Thistlethwaite PA
Nat Med 2009 Nov 15(11):1289-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christos Chadjichristos and Christos Chatziantoniou
Evaluated 18 Jan 2010


Recommended
F1000 Factor 3.2

Confirmation
Hypothesis
New Finding
 Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78.
Conrad ML, Ferstl R, …, Garn H, Renz H
J Exp Med 2009 Dec 21 206(13):2869-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / Claire Chougnet
First evaluation 15 Jan 2010 | Latest evaluation 16 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Critical role of IL-17RA in immunopathology of influenza infection.
Crowe CR, Chen K, …, Witztum JL, Kolls JK
J Immunol 2009 Oct 15 183(8):5301-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc A Williams
Evaluated 7 Jan 2010

Recommended
F1000 Factor 3.0

New Finding
Controversial
 Extended-release niacin or ezetimibe and carotid intima-media thickness.
Taylor AJ, Villines TC, …, Weissman NJ, Turco M
N Engl J Med 2009 Nov 26 361(22):2113-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Ginsberg
Evaluated 7 Jan 2010


Must Read
F1000 Factor 4.8

Confirmation
Hypothesis
New Finding
 Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
Bedoret D, Wallemacq H, …, Lekeux P, Bureau F
J Clin Invest 2009 Dec 119(12):3723-38 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marc A Williams / Mark Spears and Neil Thomson
First evaluation 6 Jan 2010 | Latest evaluation 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection.
Zernecke A, Bidzhekov K, …, Schober A, Weber C
Sci Signal 2009 2(100):ra81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ivan McMurtry
Evaluated 6 Jan 2010


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