R Scott Hawley1, 2
1Stowers Institute for Medical Research, Kansas City, MO 64110, USA
2Department of Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
* Corresponding author: rsh@stowers.org
F1000 Biology Reports 2009, 1:86
(doi: 10.3410/B1-86)
Published: 16/11/2009 © 2009 Biology Reports Ltd
The electronic version of this article is the complete one and can be found at: http://F1000.com/Reports/Biology/content/1/86
The nature of the relationship between crossing over and failed segregation in human oocytes is of obvious interest. A recent paper by Cheng and colleagues provides important insights into the distribution of crossover events (as marked by MLH1 foci) in human oocytes and raises complex questions regarding discrepancies between direct cytological assessment of exchange and measurement of crossing over by linkage analysis.