Faculty of 1000 Biology | Current Top 10

21-Mar-2010

Top 10s

Cell Biology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Cell Adhesion

Cell Growth & Division

Cell Signalling

Cellular Death & Stress Responses

Control of Gene Expression

Cytoskeleton

Membranes & Sorting

Nuclear Structure & Function

Related Sections

Chemical Biology of the Cell

Developmental Molecular Mechanisms

Leukocyte Signalling & Gene Expression

Microbial Growth & Development

Microbial Physiology & Metabolism

Morphogenesis & Cell Biology

Neuronal & Glial Cell Biology

Neuronal Signalling Mechanisms

Plant Cell Biology

Plant Genetics & Gene Expression

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	Exceptional
F1000 Factor 9.6

Hypothesis

New Finding

Abundance of ribosomal RNA gene copies maintains genome integrity.
Ide S, Miyazaki T, Maki H, Kobayashi T
Science 2010 Feb 5 327(5966):693-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Joachim Messing / Anna Chambers and Jessica Downs
Evaluated 18 Feb 2010

	Exceptional
F1000 Factor 8.1

New Finding

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis.
Link TM, Park U, …, Soloski MJ, Caterina MJ
Nat Immunol 2010 Mar 11(3):232-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bernd Nilius / Helen Goodridge and David Underhill / Aaron Neumann and Ken Jacobson
First evaluation 8 Feb 2010 | Latest evaluation 9 Mar 2010

	Exceptional
F1000 Factor 8.0

New Finding

Tech Advance

Active site remodelling accompanies thioester bond formation in the SUMO E1.
Olsen SK, Capili AD, …, Tan DS, Lima CD
Nature 2010 Feb 18 463(7283):906-12 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Walter Chazin / Michael Rape

First evaluation 9 Mar 2010 | Latest evaluation 15 Mar 2010

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.
Kalverda B, Pickersgill H, Shloma VV, Fornerod M
Cell 2010 Feb 5 140(3):360-71 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Pamela Geyer / Lucio Comai
First evaluation 16 Feb 2010 | Latest evaluation 22 Feb 2010

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.
Capelson M, Liang Y, …, Wagner U, Hetzer MW
Cell 2010 Feb 5 140(3):372-83 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Pamela Geyer / Lucio Comai
First evaluation 17 Feb 2010 | Latest evaluation 22 Feb 2010

	Must Read
F1000 Factor 6.6

Confirmation

Hypothesis

New Finding

Tech Advance

The peroxisomal importomer constitutes a large and highly dynamic pore.
Meinecke M, Cizmowski C, …, Wagner R, Erdmann R
Nat Cell Biol 2010 Mar 12(3):273-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Joseph Faust and James McNew / Christine Clayton

/ Fred Mast, Andrei Fagarasanu and Richard Rachubinski

First evaluation 11 Mar 2010 | Latest evaluation 16 Mar 2010

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells.
Melton C, Judson RL, Blelloch R
Nature 2010 Feb 4 463(7281):621-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Wenqian Hu and Jeff Coller / Amar Singh and Stephen Dalton / Martine Roussel
First evaluation 9 Feb 2010 | Latest evaluation 4 Mar 2010

	Must Read
F1000 Factor 6.4

New Finding

Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Vashisht AA, Zumbrennen KB, …, Leibold EA, Wohlschlegel JA
Science 2009 Oct 30 326(5953):718-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Caroline Philpott / Antonio Sarikas and Zhen-Qiang Pan

First evaluation 2 Feb 2010 | Latest evaluation 15 Mar 2010

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Novel Drug Target

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Andreu P, Johansson M, …, De Palma M, Coussens LM
Cancer Cell 2010 Feb 17 17(2):121-34 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Xiaojing Ma / Friedemann Kiefer
Evaluated 11 Mar 2010

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Controversial

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.
Li W, You L, …, Tempst P, Giancotti FG
Cell 2010 Feb 19 140(4):477-90 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Valera Vasioukhin / Jonathan Chernoff
First evaluation 5 Mar 2010 | Latest evaluation 10 Mar 2010

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.