Faculty of 1000 Biology | Current Top 10 > Pharmacology & Drug Discovery

Top 10s

Pharmacology & Drug Discovery

Current Top 10

All Time Top 10

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Antimicrobial Agents

Cancer Therapeutics

Cardiovascular Pharmacology

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Gastrointestinal Pharmacology

Genito-Urinary & Reproductive Pharmacology

Immunopharmacology & Hematologic Pharmacology

Molecular Pharmacology

Musculoskeletal & Dermatologic Pharmacology

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Renal Pharmacology

Respiratory Pharmacology

Toxicology

Related Sections

Bioinformatics

Biomacromolecule-Ligand Interactions

Cell Signalling

Cell Signalling & Trafficking Structures

Chemical Biology of the Cell

Directed Molecular Evolution

Genomics

Macromolecular Chemistry

Medical Genetics

Physiogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

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	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Novel Drug Target

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.
Boilard E, Nigrovic PA, …, Ware J, Lee DM
Science 2010 Jan 29 327(5965):580-3 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | William Seaman / Michael Keegan Delaney and Xiaoping Du / Kristin N Kornerup and Mauro Perretti / Robert Carter / Richard L Stevens / Serge van de Pavert and Reina Mebius

First evaluation 1 Feb 2010 | Latest evaluation 16 Mar 2010

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Controversial

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1.
Pacholec M, Bleasdale JE, …, Withka J, Ahn K
J Biol Chem 2010 Mar 12 285(11):8340-51 [abstract on PubMed] [related articles] [FREE full text]

Selected by | John Kyriakis / Bryan Roth

First evaluation 8 Mar 2010 | Latest evaluation 16 Mar 2010

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Novel Drug Target

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Heidorn SJ, Milagre C, …, Pritchard C, Marais R
Cell 2010 Jan 22 140(2):209-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Pamela Lochhead and Simon Cook / Channing Der
First evaluation 10 Feb 2010 | Latest evaluation 5 Mar 2010

	Must Read
F1000 Factor 4.9

Confirmation

Hypothesis

New Finding

Tech Advance

An in vitro translation, selection and amplification system for peptide nucleic acids.
Brudno Y, Birnbaum ME, Kleiner RE, Liu DR
Nat Chem Biol 2010 Feb 6(2):148-55 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Scott K Silverman / Mikael T Nilsson and Sherry Mowbray / Tao Liu and Dehua Pei
First evaluation 2 Feb 2010 | Latest evaluation 10 Mar 2010

	Must Read
F1000 Factor 4.8

Confirmation

Hypothesis

New Finding

Tech Advance

Identifying the amylome, proteins capable of forming amyloid-like fibrils.
Goldschmidt L, Teng PK, Riek R, Eisenberg D
Proc Natl Acad Sci U S A 2010 Feb 23 107(8):3487-92 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sophie Jackson / John Lazo

First evaluation 26 Feb 2010 | Latest evaluation 18 Mar 2010

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Controversial

Novel Drug Target

The Alzheimer's Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide.
Soscia SJ, Kirby JE, …, Tanzi RE, Moir RD
PLoS One 2010 5(3):e9505 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Thomas Kodadek

/ John Lazo

First evaluation 15 Mar 2010 | Latest evaluation 18 Mar 2010

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Novel Drug Target

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Villablanca EJ, Raccosta L, …, Traversari C, Russo V
Nat Med 2010 Jan 16(1):98-105 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Huiping Zhao and Brian Blagg / Bruno Stieger
First evaluation 28 Jan 2010 | Latest evaluation 24 Feb 2010

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.