Faculty of 1000 Biology | All Time Top 10

21-Mar-2010

Top 10s

Biochemistry

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Biocatalysis

Bioinorganic Chemistry

Biomacromolecule-Ligand Interactions

Biomimetic Chemistry

Cell Signalling & Trafficking Structures

Chemical Biology of the Cell

Directed Molecular Evolution

Experimental Biophysical Methods

Macromolecular Assemblies & Machines

Macromolecular Chemistry

Membrane Proteins & Energy Transduction

Protein Chemistry & Proteomics

Protein Folding

Small Molecule Chemistry

Structural Genomics

Structure: RNA

Structure: Replication & Repair

Structure: Transcription & Translation

Theory & Simulation

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	Exceptional
F1000 Factor 12.8

Hypothesis

New Finding

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
First evaluation 18 Mar 2004 | Latest evaluation 17 May 2004

	Exceptional
F1000 Factor 12.4

Confirmation

New Finding

Tech Advance

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, …, Neubauer G, Superti-Furga G
Nature 2002 Jan 10 415(6868):141-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Blatt / Kiyoshi Nagai / Sue Goo Rhee / Stephen Jackson / Steven Gygi / Guoping Feng / Mark Nelson / Rolf Apweiler / Marilyn Parsons / Miguel Penalva / Marie-Laure Yaspo / Ron Milligan / Michael Kiebler
First evaluation 18 Jan 2002 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 12.4

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

X-ray structure of a protein-conducting channel.
Van den Berg B, Clemons WM, …, Harrison SC, Rapoport TA
Nature 2004 Jan 1 427(6969):36-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Koreaki Ito / Karin Romisch / Jia-huai Wang / Stephen White / Tracy Palmer / Davis Ng / Senyon Choe / Ada Yonath / Kiyoshi Nagai / Manfred Schliwa / Bernd Bukau / Douglas Freymann
First evaluation 22 Dec 2003 | Latest evaluation 2 Mar 2004

	Exceptional
F1000 Factor 11.7

Confirmation

Hypothesis

New Finding

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, …, Casero RA, Shi Y
Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire
First evaluation 21 Dec 2004 | Latest evaluation 3 Feb 2005

	Exceptional
F1000 Factor 11.4

Confirmation

Hypothesis

New Finding

Structure and mechanism of the lactose permease of Escherichia coli.
Abramson J, Smirnova I, …, Kaback HR, Iwata S
Science 2003 Aug 1 301(5633):610-5 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Stephen White / Wil Konings / David Stokes / Mario Amzel / Tracy Palmer / Jonathan Javitch / Wolf B Frommer / Petra Fromme / Andreas Engel
First evaluation 6 Aug 2003 | Latest evaluation 3 Nov 2003

	Exceptional
F1000 Factor 11.3

Confirmation

New Finding

Tech Advance

Novel Drug Target

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Cherezov V, Rosenbaum DM, …, Kobilka BK, Stevens RC
Science 2007 Nov 23 318(5854):1258-65 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Xiayang Qiu / Mark von Zastrow / Peter Artymiuk / Patricia C. Weber / Ram Samudrala / Petra Fromme / Marc Caron / Susan Steinberg
First evaluation 31 Oct 2007 | Latest evaluation 30 Jan 2009

	Exceptional
F1000 Factor 11.3

Hypothesis

New Finding

Tech Advance

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Rasmussen SG, Choi HJ, …, Weis WI, Kobilka BK
Nature 2007 Nov 15 450(7168):383-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Leonardo Pardo / Fred Dyda / Carmen Dessauer / Arthur Christopoulos / Patricia C. Weber / Ian Hall / Marc Caron / Stephan Nussberger
First evaluation 30 Oct 2007 | Latest evaluation 3 Mar 2008

	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 11.1

Confirmation

New Finding

Tech Advance

STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis.
Willig KI, Rizzoli SO, …, Jahn R, Hell SW
Nature 2006 Apr 13 440(7086):935-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Lennart Brodin / David Stephens / Berl R Oakley / Volker Haucke / Manfred Schliwa / Peter McPherson / Josep Rizo / Karolin Luger / Michael Kiebler
First evaluation 19 Apr 2006 | Latest evaluation 10 Apr 2007

	Exceptional
F1000 Factor 11.1

Confirmation

Hypothesis

New Finding

Prokaryotic origin of the actin cytoskeleton.
van den Ent F, Amos LA, Löwe J
Nature 2001 Sep 6 413(6851):39-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Eva Nogales / Ford Doolittle / Keiichi Namba / Robert Liddington / Tony Crowther / Piet de Boer / Norma Andrews / Amy McGough / Tracy Palmer
First evaluation 1 Oct 2001 | Latest evaluation 18 Jan 2002

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.