Faculty of 1000 Biology | All Time Top 10

22-Mar-2010

Top 10s

Physiology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Cardiovascular Physiology/Circulation

Endocrinology

Gastrointestinal Physiology

Integrative Physiology

Muscle & Connective Tissue

Neural Homeostasis

Physiogenomics

Renal, Fluid & Electrolyte Physiology

Reproductive Physiology

Respiratory Physiology

Related Sections

Behavioural Neuroscience

Cell Signalling

Cognitive Neuroscience

Genomics

Immune Response

Immunity to Infections

Medical Genetics

Membranes & Sorting

Morphogenesis & Cell Biology

Motor Systems

Neurodevelopment

Neuronal Signalling Mechanisms

Pattern Formation

Sensory Systems

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	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Tech Advance

Matrix elasticity directs stem cell lineage specification.
Engler AJ, Sen S, Sweeney HL, Discher DE
Cell 2006 Aug 25 126(4):677-89 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kenneth Yamada / Ray Rodgers / Carol Otey / Paul Bornstein / Avri Ben-Ze'ev / Michel Labouesse / Thomas Egelhoff / Deborah Andrew / Amy Wagers
First evaluation 30 Aug 2006 | Latest evaluation 3 Sep 2007

	Exceptional
F1000 Factor 10.9

New Finding

Tech Advance

Multimodal fast optical interrogation of neural circuitry.
Zhang F, Wang LP, …, Gottschalk A, Deisseroth K
Nature 2007 Apr 5 446(7136):633-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Tullio Pozzan / Edvard I Moser / Eileen Lafer / David P Wolfer / Shai Shaham / Joel Elmquist / Ellen A Lumpkin / Michael Kiebler
First evaluation 10 Apr 2007 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 10.8

New Finding

Tech Advance

ChIP-seq accurately predicts tissue-specific activity of enhancers.
Visel A, Blow MJ, …, Rubin EM, Pennacchio LA
Nature 2009 Feb 12 457(7231):854-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Filippo Rijli / Cristina A. de Frutos and Alejandro Barrallo-Gimeno and M. Angela Nieto / Megana Prasad and Andrew S McCallion / Fernando Casares / Hans van Bokhoven / Jane Johnson / Michael Zhang / Donald Nierlich and Aldons J Lusis
First evaluation 24 Feb 2009 | Latest evaluation 15 Jun 2009

	Exceptional
F1000 Factor 10.8

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

An obesity-associated gut microbiome with increased capacity for energy harvest.
Turnbaugh PJ, Ley RE, …, Mardis ER, Gordon JI
Nature 2006 Dec 21 444(7122):1027-131 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Robertson / Joel Elmquist / Matthias Maiwald / Liang Tong / Joanna Goldberg / Marc Lecuit / Stefan Kaufmann / Joe Heitman / David Bilder
First evaluation 2 Jan 2007 | Latest evaluation 21 Feb 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Tech Advance

Controversial

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, Gurley SB, …, Le TH, Coffman TM
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17985-90 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Matthew Breyer / Soeren Sheikh / Raymond Harris / Anna Dominiczak / Tom Lohmeier / David J Webb / Robert Carey
First evaluation 17 Nov 2006 | Latest evaluation 25 Jul 2007

	Exceptional
F1000 Factor 10.6

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
Zhou Q, Brown J, …, Rajagopal J, Melton DA
Nature 2008 Oct 2 455(7213):627-32 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anthony Means / Phillip Newmark / L Mullins and John Mullins / Raghavendra Mirmira / Ray Rodgers / Ivana Novak / Ulf Pettersson
First evaluation 4 Sep 2008 | Latest evaluation 9 Dec 2008

	Exceptional
F1000 Factor 10.6

Hypothesis

New Finding

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL
Cell 2005 Jul 15 122(1):107-18 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Joern Piel / Torben Lund / Emanuela Handman / Ben Lugtenberg / Rino Rappuoli / Shiv Pillai / Richard Grencis / Lora Hooper
First evaluation 25 Jul 2005 | Latest evaluation 15 Dec 2005

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Novel Drug Target

Disruption of the Ang II type 1 receptor promotes longevity in mice.
Benigni A, Corna D, …, Coffman TM, Remuzzi G
J Clin Invest 2009 Mar 119(3):524-30 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Robert Carey / Jonatan Barrera and Norma A. Bobadilla / Andreas Deussen / Bharath Wootla and Dominique Eladari / Mark Chappell
First evaluation 19 Mar 2009 | Latest evaluation 10 Nov 2009

	Exceptional
F1000 Factor 10.4

Confirmation

Hypothesis

New Finding

Controversial

Novel Drug Target

AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anthony Means / James Timmons / Fredric Wondisford / Markus Ruegg / Klementina Fon Tacer and David Mangelsdorf / Katrina L Bogan and Charles Brenner
First evaluation 12 Aug 2008 | Latest evaluation 30 Oct 2008

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Tech Advance

Novel Drug Target

Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.
Binshtok AM, Bean BP, Woolf CJ
Nature 2007 Oct 4 449(7162):607-10 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bernd Nilius / Ian Hall / Michael Andresen / David Triggle / Gavril Pasternak / Emery Brown / Jaime García-Añoveros
First evaluation 12 Oct 2007 | Latest evaluation 24 Apr 2008

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.