Faculty of 1000 Biology | Current Top 10

9-Feb-2010

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	Exceptional
F1000 Factor 9.7

Hypothesis

New Finding

Endogenous non-retroviral RNA virus elements in mammalian genomes.
Horie M, Honda T, …, Coffin JM, Tomonaga K
Nature 2010 Jan 7 463(7277):84-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Charles Chiu / David Leib / David Wang

First evaluation 14 Jan 2010 | Latest evaluation 8 Feb 2010

	Exceptional
F1000 Factor 9.6

New Finding

Tech Advance

Novel Drug Target

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Ise W, Kohyama M, …, Murphy TL, Murphy KM
Nat Immunol 2010 Feb 11(2):129-35 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bryce A Binstadt / Xingfeng Bao and Minoru Fukuda

First evaluation 29 Jan 2010 | Latest evaluation 8 Feb 2010

	Exceptional
F1000 Factor 9.6

Confirmation

Hypothesis

New Finding

Aire's partners in the molecular control of immunological tolerance.
Abramson J, Giraud M, Benoist C, Mathis D
Cell 2010 Jan 8 140(1):123-35 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Shiv Pillai / Bruno Kyewski

First evaluation 28 Jan 2010 | Latest evaluation 3 Feb 2010

	Exceptional
F1000 Factor 8.2

New Finding

Novel Drug Target

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Doi M, Takahashi Y, …, van der Horst GT, Okamura H
Nat Med 2010 Jan 16(1):67-74 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Chung Owyang / Robert Carey / Zachary Weil and Randy Nelson
First evaluation 19 Jan 2010 | Latest evaluation 25 Jan 2010

	Exceptional
F1000 Factor 8.0

New Finding

Novel Drug Target

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.
Boilard E, Nigrovic PA, …, Ware J, Lee DM
Science 2010 Jan 29 327(5965):580-3 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | William Seaman / Michael Keegan Delaney and Xiaoping Du

First evaluation 1 Feb 2010 | Latest evaluation 8 Feb 2010

	Exceptional
F1000 Factor 8.0

New Finding

Tech Advance

Exome sequencing identifies the cause of a mendelian disorder.
Ng SB, Buckingham KJ, …, Shendure J, Bamshad MJ
Nat Genet 2010 Jan 42(1):30-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard F Wintle and Stephen Scherer / Steven Salzberg

First evaluation 25 Jan 2010 | Latest evaluation 3 Feb 2010

	Exceptional
F1000 Factor 8.0

New Finding

Controversial

Mitosomes in Entamoeba histolytica contain a sulfate activation pathway.
Mi-ichi F, Abu Yousuf M, Nakada-Tsukui K, Nozaki T
Proc Natl Acad Sci U S A 2009 Dec 22 106(51):21731-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | C Graham Clark / Jacqueline Upcroft
First evaluation 12 Jan 2010 | Latest evaluation 1 Feb 2010

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Novel Drug Target

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
Iliopoulos D, Hirsch HA, Struhl K
Cell 2009 Nov 13 139(4):693-706 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kai Wucherpfennig / Katya V Melnik-Martinez and Amy Pasquinelli
First evaluation 18 Jan 2010 | Latest evaluation 26 Jan 2010

	Must Read
F1000 Factor 6.7

Confirmation

New Finding

Tech Advance

Controversial

Recreation of the terminal events in physiological integrin activation.
Ye F, Hu G, …, Taylor KA, Ginsberg MH
J Cell Biol 2010 Jan 11 188(1):157-73 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Herbert B Schiller and Reinhard Fässler / Mark Morgan and Martin Humphries / Kenneth Yamada / Michael March and Eric Long

First evaluation 15 Jan 2010 | Latest evaluation 4 Feb 2010

	Must Read
F1000 Factor 6.6

Confirmation

Hypothesis

New Finding

An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos.
Monier B, Pélissier-Monier A, Brand AH, Sanson B
Nat Cell Biol 2010 Jan 12(1):60-5; sup pp 1-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Valeri Vasioukhin / Ken Jacobson

/ Clemens Kiecker and Andrew Lumsden

First evaluation 11 Jan 2010 | Latest evaluation 9 Feb 2010

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.