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 HIDDEN JEWELS | Pharmacology & Drug Discovery | calculated on 19 March 2010
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1
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Controversial
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1.
Pacholec M, Bleasdale JE, …, Withka J, Ahn K
J Biol Chem 2010 Mar 12 285(11):8340-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Kyriakis / Bryan Roth
First evaluation 8 Mar 2010 | Latest evaluation 16 Mar 2010
 
2
Recommended
F1000 Factor 3.0

Hypothesis
GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution.
Warnecke T, Hurst LD
Mol Syst Biol 2010 6:340 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Hu
Evaluated 3 Mar 2010
 
3
Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Controversial
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.
Lee Y, Auh SL, …, Weichselbaum RR, Fu YX
Blood 2009 Jul 16 114(3):589-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Olga Afanasiev and Paul Nghiem
Evaluated 8 Mar 2010
 
4
Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Controversial
Novel Drug Target
The Alzheimer's Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide.
Soscia SJ, Kirby JE, …, Tanzi RE, Moir RD
PLoS One 2010 5(3):e9505 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Kodadek / John Lazo
First evaluation 15 Mar 2010 | Latest evaluation 18 Mar 2010
 
5
Recommended
F1000 Factor 3.0

New Finding
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
Teng L, Zhao J, …, Ma L, Pei G
Cell Res 2010 Feb 20(2):138-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Bockaert
Evaluated 9 Mar 2010
 
6
Recommended
F1000 Factor 3.0

New Finding
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
Singh LR, Gupta S, …, Kraus JP, Kruger WD
PLoS Genet 2010 Jan 6(1):e1000807 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ruma Banerjee
Evaluated 5 Mar 2010
 
7
Recommended
F1000 Factor 3.0

Confirmation
Fragment-Based Deconstruction of Bcl-x(L) Inhibitors.
Barelier S, Pons J, …, Lancelin JM, Krimm I
J Med Chem 2010 Mar 1 [abstract on PubMed] [related articles] [full text]
Selected by | Jefferson Tilley
Evaluated 8 Mar 2010
 
8
Recommended
F1000 Factor 3.0

New Finding
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
Ramer R, Merkord J, Rohde H, Hinz B
Biochem Pharmacol 2010 Apr 1 79(7):955-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lesley Ford and Roger Pertwee
Evaluated 10 Mar 2010
 
9
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaudia Budzyn and David Harrison
Evaluated 20 May 2008
 
10
Must Read
F1000 Factor 6.0

New Finding
Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.
Lapensee EW, Lapensee CR, …, Afton S, Ben-Jonathan N
Cancer Lett 2010 Apr 28 290(2):167-173 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin van den Berg
Evaluated 16 Mar 2010

Hidden Jewels Top 10 lists are generated every day and comprise only papers published in less widely read journals (the grouping of which is the same for all Faculties; therefore, whilst some of these journals may be considered 'high profile' in their immediate Faculty, they are included in the Hidden Jewels lists because they probably will not be so obvious to people outside that specific Faculty). The Hidden Jewels list of papers is ordered by the number of times a paper's evaluation(s) has been viewed over the past 14 days.


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