Faculty of 1000 Biology | Most-viewed Top 10

18-Mar-2010

Top 10s

Evolutionary Biology

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Animal Genetics

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Developmental Molecular Mechanisms

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Medical Genetics

Microbial Evolution & Genomics

Morphogenesis & Cell Biology

Nuclear Structure & Function

Pattern Formation

Plant Genetics & Gene Expression

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	Exceptional
F1000 Factor 9.6

Hypothesis

New Finding

Abundance of ribosomal RNA gene copies maintains genome integrity.
Ide S, Miyazaki T, Maki H, Kobayashi T
Science 2010 Feb 5 327(5966):693-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Joachim Messing / Anna Chambers and Jessica Downs
Evaluated 18 Feb 2010

	Must Read
F1000 Factor 6.7

Confirmation

New Finding

Tech Advance

The genetic landscape of a cell.
Costanzo M, Baryshnikova A, …, Andrews BJ, Boone C
Science 2010 Jan 22 327(5964):425-31 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Eulalia de Nadal and Francesc Posas / Jurg Bahler / Nicholas P Tatonetti and Russ Altman / Jamie Snider and Igor Stagljar
First evaluation 2 Feb 2010 | Latest evaluation 16 Feb 2010

	Exceptional
F1000 Factor 10.0

Hypothesis

New Finding

Tech Advance

Direct conversion of fibroblasts to functional neurons by defined factors.
Vierbuchen T, Ostermeier A, …, Südhof TC, Wernig M
Nature 2010 Feb 25 463(7284):1035-41 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Magdalena Goetz / Arnold Kriegstein / Andy Groves / Avinash Bhandoola

First evaluation 4 Feb 2010 | Latest evaluation 18 Mar 2010

	Exceptional
F1000 Factor 9.0

New Finding

Refutation

Dynamic interpretation of hedgehog signaling in the Drosophila wing disc.
Nahmad M, Stathopoulos A
PLoS Biol 2009 Sep 7(9):e1000202 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Alon Goron, James Zou and Brad Bernstein
Evaluated 1 Mar 2010

	Exceptional
F1000 Factor 10.2

Confirmation

Hypothesis

New Finding

Tech Advance

An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos.
Monier B, Pélissier-Monier A, Brand AH, Sanson B
Nat Cell Biol 2010 Jan 12(1):60-5; sup pp 1-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Valera Vasioukhin / Ken Jacobson / Clemens Kiecker and Andrew Lumsden / Alpha Yap / Michel Labouesse
First evaluation 11 Jan 2010 | Latest evaluation 2 Mar 2010

	Must Read
F1000 Factor 6.4

Hypothesis

Controversial

Four stages of a scientific discipline; four types of scientist.
Shneider AM
Trends Biochem Sci 2009 May 34(5):217-23 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Etienne Joly / Armen Mulkidjanian and Michael Galperin
First evaluation 3 Aug 2009 | Latest evaluation 10 Aug 2009

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

The continuity of protein structure space is an intrinsic property of proteins.
Skolnick J, Arakaki AK, Lee SY, Brylinski M
Proc Natl Acad Sci U S A 2009 Sep 15 106(37):15690-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Nick Grishin
Evaluated 3 Mar 2010

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

Controversial

Mutational robustness can facilitate adaptation.
Draghi JA, Parsons TL, Wagner GP, Plotkin JB
Nature 2010 Jan 21 463(7279):353-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jason Shapiro and Paul Turner
Evaluated 10 Mar 2010

	Exceptional
F1000 Factor 8.1

Hypothesis

New Finding

Tech Advance

A minimal sequence code for switching protein structure and function.
Alexander PA, He Y, …, Orban J, Bryan PN
Proc Natl Acad Sci U S A 2009 Dec 15 106(50):21149-54 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Alina Peterson and Adolfo Garcia-Sastre / Gira Bhabha and H Jane Dyson / Nick Grishin
First evaluation 6 Jan 2010 | Latest evaluation 2 Mar 2010

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Regulation of alternative splicing by histone modifications.
Luco RF, Pan Q, …, Pereira-Smith OM, Misteli T
Science 2010 Feb 19 327(5968):996-1000 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Andrea Mattevi / Leonie Ringrose
First evaluation 17 Feb 2010 | Latest evaluation 2 Mar 2010

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