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 MOST VIEWED PAPERS | Biochemistry | calculated on 9 February 2010
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1
Must Read
F1000 Factor 6.0

Hypothesis
Controversial
 Reactome array: forging a link between metabolome and genome.
Beloqui A, Guazzaroni ME, …, Golyshin PN, Ferrer M
Science 2009 Oct 9 326(5950):252-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ben Davis
Dissenters | Michael Gelb / David Cane
First evaluation 20 Jan 2010 | Latest evaluation 28 Jan 2010

 
2
Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Tech Advance
 Toward a quantitative theory of intrinsically disordered proteins and their function.
Liu J, Faeder JR, Camacho CJ
Proc Natl Acad Sci U S A 2009 Nov 24 106(47):19819-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Vladimir Uversky
Evaluated 26 Jan 2010
 
3
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Tech Advance
 Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts.
Jensen MR, Salmon L, Nodet G, Blackledge M
J Am Chem Soc 2010 Jan 11 [abstract on PubMed] [related articles] [full text]
Selected by | Vladimir Uversky
Evaluated 26 Jan 2010
 
4
Recommended
F1000 Factor 3.0

Tech Advance
 Infrared laser-mediated gene induction in targeted single cells in vivo.
Kamei Y, Suzuki M, …, Funatsu T, Yuba S
Nat Methods 2009 Jan 6(1):79-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Ebbinghaus and Martin Gruebele
Evaluated 25 Jan 2010
 
5
Recommended
F1000 Factor 3.0

Tech Advance
 The Negatome database: a reference set of non-interacting protein pairs.
Smialowski P, Pagel P, …, Frishman D, Ruepp A
Nucleic Acids Res 2010 Jan 38:D540-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Willson
Evaluated 2 Feb 2010
 
6
Must Read
F1000 Factor 6.0

Tech Advance
 A Small Molecule-Regulated Guanine Nucleotide Exchange Factor.
Goreshnik I, Maly DJ
J Am Chem Soc 2009 Dec 18 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Gelb
Evaluated 22 Jan 2010
 
7
Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Tech Advance
 A minimal sequence code for switching protein structure and function.
Alexander PA, He Y, …, Orban J, Bryan PN
Proc Natl Acad Sci U S A 2009 Dec 15 106(50):21149-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alina Peterson and Adolfo Garcia-Sastre / Gira Bhabha and H Jane Dyson
First evaluation 6 Jan 2010 | Latest evaluation 12 Jan 2010
 
8
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 MNAzymes, a versatile new class of nucleic acid enzymes that can function as biosensors and molecular switches.
Mokany E, Bone SM, …, Doan TB, Todd AV
J Am Chem Soc 2010 Jan 27 132(3):1051-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Russ Hille
Evaluated 4 Feb 2010
 
9
Must Read
F1000 Factor 6.0

New Finding
 Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch.
Kulshina N, Baird NJ, Ferré-D'Amaré AR
Nat Struct Mol Biol 2009 Dec 16(12):1212-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aaron S Burton and Niles Lehman
Evaluated 27 Jan 2010
 
10
Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Tech Advance
 An in vitro translation, selection and amplification system for peptide nucleic acids.
Brudno Y, Birnbaum ME, Kleiner RE, Liu DR
Nat Chem Biol 2010 Feb 6(2):148-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Scott K Silverman
Evaluated 2 Feb 2010

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