homefeedbacksupportlog on 21-Mar-2010 
  Search
 
   
 
  Top 10s
 Pharmacology & Drug Discovery
  Current Top 10
  All Time Top 10
  Most-viewed Top 10
  Hidden Jewels Top 10

  Sections Covered
Antimicrobial Agents
Cancer Therapeutics
Cardiovascular Pharmacology
Drug Discovery & Design
Endocrine & Metabolic Pharmacology
Gastrointestinal Pharmacology
Genito-Urinary & Reproductive Pharmacology
Immunopharmacology & Hematologic Pharmacology
Molecular Pharmacology
Musculoskeletal & Dermatologic Pharmacology
Neuropharmacology & Psychopharmacology
Pharmacogenomics
Pharmacokinetics & Drug Delivery
Renal Pharmacology
Respiratory Pharmacology
Toxicology
Related Sections
Bioinformatics
Biomacromolecule-Ligand Interactions
Cell Signalling
Cell Signalling & Trafficking Structures
Chemical Biology of the Cell
Directed Molecular Evolution
Genomics
Macromolecular Chemistry
Medical Genetics
Physiogenomics
Protein Chemistry & Proteomics
Small Molecule Chemistry


 MOST VIEWED PAPERS | Pharmacology & Drug Discovery | calculated on 19 March 2010
 browse faculty | show Most Viewed Papers in

to email [Help]


1
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Controversial
 SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1.
Pacholec M, Bleasdale JE, …, Withka J, Ahn K
J Biol Chem 2010 Mar 12 285(11):8340-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Kyriakis / Bryan Roth
First evaluation 8 Mar 2010 | Latest evaluation 16 Mar 2010
 
2
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Blueprint for antimicrobial hit discovery targeting metabolic networks.
Shen Y, Liu J, …, Wiest O, Oltvai ZN
Proc Natl Acad Sci U S A 2010 Jan 19 107(3):1082-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Mar 2010
 
3
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 A key role for orexin in panic anxiety.
Johnson PL, Truitt W, …, Brundin L, Shekhar A
Nat Med 2010 Jan 16(1):111-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W von Geldern
Evaluated 8 Mar 2010
 
4
Must Read
F1000 Factor 4.9

Confirmation
Hypothesis
New Finding
Tech Advance
 An in vitro translation, selection and amplification system for peptide nucleic acids.
Brudno Y, Birnbaum ME, Kleiner RE, Liu DR
Nat Chem Biol 2010 Feb 6(2):148-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Scott K Silverman / Mikael T Nilsson and Sherry Mowbray / Tao Liu and Dehua Pei
First evaluation 2 Feb 2010 | Latest evaluation 10 Mar 2010
 
5
Recommended
F1000 Factor 3.0

Tech Advance
 Microbial production of fatty-acid-derived fuels and chemicals from plant biomass.
Steen EJ, Kang Y, …, Del Cardayre SB, Keasling JD
Nature 2010 Jan 28 463(7280):559-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Priyanka Verma and Rajesh Gokhale
Evaluated 8 Mar 2010
 
6
Exceptional
F1000 Factor 10.4

Hypothesis
New Finding
Novel Drug Target
 Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.
Boilard E, Nigrovic PA, …, Ware J, Lee DM
Science 2010 Jan 29 327(5965):580-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Seaman / Michael Keegan Delaney and Xiaoping Du / Kristin N Kornerup and Mauro Perretti / Robert Carter / Richard L Stevens / Serge van de Pavert and Reina Mebius
First evaluation 1 Feb 2010 | Latest evaluation 16 Mar 2010

 
7
Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
Controversial
 Dynamics of intracellular bacterial replication at the single cell level.
Helaine S, Thompson JA, …, Boyle C, Holden DW
Proc Natl Acad Sci U S A 2010 Feb 23 107(8):3746-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lawrence R Mulcahy and Kim Lewis
Evaluated 10 Mar 2010
 
8
Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.
Rihel J, Prober DA, …, Peterson RT, Schier AF
Science 2010 Jan 15 327(5963):348-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 9 Mar 2010
 
9
Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Novel Drug Target
 Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Heidorn SJ, Milagre C, …, Pritchard C, Marais R
Cell 2010 Jan 22 140(2):209-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pamela Lochhead and Simon Cook / Channing Der
First evaluation 10 Feb 2010 | Latest evaluation 5 Mar 2010

 
10
Recommended
F1000 Factor 3.0

Hypothesis
 GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution.
Warnecke T, Hurst LD
Mol Syst Biol 2010 6:340 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Hu
Evaluated 3 Mar 2010

Most Viewed lists are generated every day and reflect use of F1000 Biology over the preceding 14 day period.

© 1999-2010 Faculty of 1000 Ltd unless otherwise stated. < info@f1000.com >   Terms and conditions   Legal info